Abstract
Summary
Bioassays of effects on clotting tests, due to preincubates of various combinations of the five basic factors involved in enzymic (TK) thrombin generation, support a new idea that such assays are very sensitive to small amounts of thrombokinase, and that the reactivities of TK are determined by availabilities of the three cofactors, Ca2+, factor V, and phospholipid (PL). The untenable theory of a V→ Va activation can now be reinterpreted in the light of these new data.
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