Amyloid. VIII. On Strain Variability in Experimental Murine Amyloidosis

Abstract

Summary

Variability due to strain and sex in experimental amyloidosis of mice was investigated. When given a single intraperitoneal injection of 0.25 ml of a Freund-type emulsion containing additional heat-killed M. butyricum (40 mg/ml), all of 10 strains of mice investigated (NBL/N, C₃H/HeN, AKR/N, AL/N, DBA/2N, C57/6N, STR/N, A/HeN, AALF₁; and general purpose Swiss albino) developed amyloidosis. However, strain-dependent differences in the incidence and degree of severity of the disease were note. It was also noted that the strains which are highly susceptible to experimental amyloidosis are the ones reported in literature to be least prone to develop spontaneous amyloidosis and vice versa. Both males and females of a single strain investigated, namely C₃H, developed amyloidosis to a similar degree.