Abstract
Summary
The exposure of 3T6 fibroblasts to the lathyrogen β-aminopropionitrile fumarate caused a reduction in proliferation of the cells but had no effect upon viability. Chemical analysis for the production of collagen as measured by free, peptide, and protein-bound hydroxyproline showed that the lathyrogen exerted a stimulative effect. The lathyrogen-treated cells produced approximately twice the amount of hydroxyproline as did the control cells. The data also indicate that the initial stages of collagen production are not altered and that the depression in proliferation signifies a change in overall metabolism rather than a direct toxic effect.
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