Abstract
Summary
Single injections of rat thyroid extract with complete Freund adjuvant were not consistent in eliciting significant thyroid pathology in Lewis rats. Identical treatment accompanied by a simultaneous but separate injection of 100 billion killed pertussis organisms was consistently effective in inducing marked thyroid changes at an earlier time. Lewis rats developed thyroid lesions approximately 1 week earlier than Fischer 344 rats receiving the same treatment. Pertussis vaccine also seemed to increase the level of circulating autoantibodies to thyroid.
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