Abstract
Summary
An anabolic androgenic steroid, Dianabol (methandrostenolone), caused marked inhibition of proliferation when added to carcinoma and sarcoma cell cultures at concentrations of 0.25-25 μg/ml. Similar concentrations of the drug were noninhibitory when added to cultures of diploid, embryonic, and viral-transformed male or female fibroblasts. Protein and RNA synthesis, measured by uptake of lysine-14C and uridine-3H, was unaltered by the Dianabol in the sensitive as well as the insentive cell types.
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