Abstract
Summary
Passively induced hyperthermia significantly delayed or prevented lethal CNS infections of mice produced by a line of type 1 dengue virus with a history of 33 serial mouse brain passages (MP-33) but not one with a history of 125 passages (MP-125). This effect was not due to any enhancement of interferon production in the brain but was the result of a reduced rate of viral multiplication. Permanent recovery from MP-33 infection in hyperthermic animals was correlated with the appearance of the immune response.
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