Abstract
Summary
Although in short-term experiments pituitary isografts have shown a direct local effect on the growth of the mammary gland, isografts of a hypophysis into the fat pads of the mammary glands showed no local effect on the incidence or an earlier appearance of mammary tumors near the site of implantation. The hormonal inciting influence is assumed to be so great that a local effect cannot be recognized. After isografting of hypophysis, a remarkable shift in the localization of the mammary tumors occurs: more tumors develop in the fourth and fifth pairs of glands than in untreated animals.
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