Abstract
Summary
The local effects of graded increases and decreases of PaCO2 and pH on cerebral vascular resistance were determined in isolated dog heads. Two preparations were utilized: In the first series, a donor dog was included in the extracorporeal circulation to supply blood to the constant flow perfused, decapitate head; in the second series, the donor dog was replaced with an oxygenator-reservoir system. Results indicate that the direct effect of increasing paCO2 and decreasing pH is a fall of cerebral vascular resistance and vice versa.
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