Phospholipid Metabolism during Amino Acid Transport in Hamster Small Intestine ∗

Abstract

Summary

Previous studies of phospholipid metabolism during active transport have used ³²P and ¹⁴C glycerol as a measure of phospholipid metabolism. In this investigation linoleic-1-¹⁴C-albumin and ³²P were used in studying phospholipid metabolism during amino acid transport in the hamster small intestine. The results demonstrate an augmented incorporation of linoleic-1-¹⁴C acid into lecithin at the site of maximum amino acid transport. The enhanced incorporation of fatty acid into lecithin may be related to: (a) a diacyl-monoacyl phosphoglyceride cycle resulting in a lamellar-micellar shift in this membrane phospholipid associated with transport, and/or (b) enchanced phospholipid fatty acid oxidation occurring with transport, or (c) other undefined mechanisms.