Abstract
Summary
A system was developed for studying the interactions between Friend leukemia virus (FV) and hemopoietic cells which lead to viral replication and leukemic transformation. The system involves the use of heavily irradiated mice which cannot support the growth of FV in the absence of added hemopoietic cells. When the heavily irradiated mice were injected with the suspensions of virus and normal spleen or bone marrow cells, FV and FV-induced tumor cells were recovered from the spleens of these mice. In vitro incubation (37° for 30 min) of cells and virus prior to injection into heavily irradiated mice increased the yield of recoverable virus.
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