Abstract
Summary
Testosterone propionate treatment of intact 10-day-old cockerels significantly depressed renal gulonate NADP oxidoreductase activity; after a delay there was a significant decrease in kidney and liver vitamin C concentrations. Administration of corticosterone did not affect the renal biosynthesis of ascorbic acid, but did result in significant decreases in kidney and liver vitamin C concentrations. The decline in tissue vitamin C concentration 4 days after cessation of androgen treatment may have been caused by the previous depression of renal enzyme activity, but the decrease in tissue vitamin C after corticoid treatment showed no such correlation and was interpreted as a nonenzymatic hormonal effect on vitamin C utilization or transport by the tissues/Androgen treatment of 10-week-old capons also resulted in a significant reduction of renal gulonate NADP oxidoreductase activity. However renal and hepatic vitamin C concentrations were significantly elevated in this instance, possibly because insufficient time had elapsed for a vitamin depletion response.
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