Adenovirus Susceptibility to Interferon

Abstract

Summary

The sensitivity of adenovirus Types 2, 7, and 12 to moderate amounts of human tissue culture interferon was demonstrated in plaque-reduction assays using primary and secondary HEK cell cultures. The findings for Ad. Type-2 were extended to another species using rabbit serum interferon in yield-inhibition assays done in an established rabbit heart fibroblast cell line. These results indicate that at least some members of the adenovirus group are indeed susceptible to interferon, although to a clearly lesser extent than are many other viruses. The implications of these findings for the possible use of interferon in examining in vitro the mechanisms of viral oncogenesis are considered.