Abstract
Summary
An examination of the level of serum cholesterol in monkeys following convulsive seizures induced by electroshock or pentamethylenetetrazol (Metrazol) indicated that no significant changes in the metabolic pattern took place within the first hour. Observed increases in total serum solids, proteins, and cholesterol were due largely, if not entirely, to withdrawal of water from circulation. Metrazol, but not electroshock, caused a significant decrease in serum cholesterol 24 hr after a single treatment. This decrease was apparently due to a specific inhibition of sterol biosynthesis.
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