Abstract
Experiments with dilutions of hirudin show that the stronger the antithrombic solution, the less calcium is needed for optimum coagulation; in other words that, to a certain extent, they bear an inverse ratio to each other. In the accompanying table we see tests of plasma containing hirudin (1 : 40,000) to which 3, 4, 5 and 6 drops of a calcium solution were added. We may note that where only 2 drops of hirudin were added, the clotting-time was in all four instances the same; when three drops were added the time was delayed where 6 drops of calcium were used; and where four drops of hirudin were present, coagulation was markedly delayed in both the tubes containing 5 and 6 drops of the calcium solution.
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