Abstract
Conclusion
Injection of mice with 30 mg of GSH, especially intravenously, was complicated by the unphysiologic, extracellular distribution of the exogenous glutathione. The GSH given to mice to replace nonprotein sulfhydryl lost as a result of endotoxin shock provided only slight protection. Survival was significantly improved by intraperitoneal injection of 30 mg of GSH 4 hr before the endotoxin. Thus, there appears to be little therapeutic potential for GSH in endotoxin shock.
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