Abstract
Summary
Mononuclear cell infiltration of an egg albumin-induced skin lesion is preceded by infiltration with polymorphonuclear cells. In rabbits in which mononuclear cell infiltration of this lesion was suppressed by 6-MP, the possible effects of immunosuppression on the lysosomal enzyme content of the polymorphonuclear cells was investigated. The acid phosphatase, beta glucuronidase, and ribonuclease content of extracts of the polymorphonuclear cells of these animals were determined. In spite of adequate suppression of mononuclear infiltration of the induced skin lesion, no difference in the concentration of the three enzymes in the polymorphonuclear cells was noted. The results indicate that the failure of mononuclear cell infiltration in 6-MP-treated animals is not due to an effect on lysosomal enzyme synthesis in cells of the neutrophil series.
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