Abstract
Summary
Previous observations that testosterone incrases production of the ESF and the REF are confirmed and extended. The combination of testosterone and hypoxia act synergistically in augmenting plasma ESF and REF activities. The depressive effect of estradiol on ESF production is not accompanied by a decrease in REF activity. However, the serum from estradiol-treated rats exhibits a reduced capacity to serve as a substrate for the REF in the generation of the ESF.
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