Abstract
Summary
A study of the structural analogs of diethylcarbamazine reveals the requirement for a carboxamide grouping and a saturated or unsaturated ring containing nitrogen for optimal inhibition of SRS-Arat release. Diethylcarbamazine and its analogs do not act by interfering with PMN leukocyte viability and they do not inhibit the homocytotropic antibody-mediated release of histamme and serotonin. Conversely, disodium cromoglycate suppresses the latter pathway without inhibiting the antigen-induced release of SRS-Arat. Neither diethylcarbamazine nor disodium cromoglycate antagonizes the pharmacologic activity of histamine or SRS-Arat. The use of these agents permits further dissociation of the pathways leading to the immunologic release of SRS-Arat and histamine in the rat by selective pharmacologic inhibition.
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