Abstract
Summary
A median eminence implant of prolactin significantly lowered anterior pituitary prolactin content and concentration in female rats. Injection of 1.0 μg of estradiol benzoate daily for 5 days was unable to counteract this action of the ME implant of prolactin, whereas 5 μg was only partially effective. However, injection of 10.0 μg of estradiol benzoate daily was as effective in increasing anterior pituitary prolactin levels in the presence as in the absence of an ME implant of prolactin. These results suggest that circulating levels of prolactin, by acting on the hypothalamus, may be able to modify the action of estrogen in promoting prolactin secretion.
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