Abstract
Summary
Hexose monophosphate shunt (HMPS) dehydrogenase activity was measured in the remaining kidney at frequent intervals for 4 days after unilateral nephrectomy of rats. Total HMPS dehydrogenase activity in the residual kidney began to increase 18 hr after nephrectomy and was doubled (1.97) at 72 hr, where it remained at 96 hr (1.97). While the total soluble protein (20,000 g supernate) showed a continuous increase beginning about 18 hr after nephrectomy, HMPS dehydrogenase specific activity exhibited a biphasic pattern with peaks at 36 hr (25% increment) and 72 hr (40% increment). The data indicate that preferential synthesis of the HMPS dehydrogenase enzymes (G6PD and 6PGD) is an early response of the remaining kidney to unilateral nephrectomy.
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