Abstract
Summary
Whole-body γ-irradiation (750 R) affected both AP and ATPase activities in 4 rat organs with similar changes in the period from 3 to 8 days postirradiation. However, the magnitude of these changes was different from one organ to another. Solutions of ATPase and AP (in vitro) were inactivated by irradiation. The former enzyme was radioresistant as evidenced by its D37 of 55 krads compared to D37 of 9 krads for AP. Cysteine (0.1 mM) altered the D37 of both AP and ATPase to 21 and 87 krads, respectively, whereas 4A1N (0.1 mM) changed the D37 of AP to 180 and ATPase to 148 krads. Maximum protection (20-fold) afforded by 4A1N was noted for AP.
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