Abstract
Summary
Guinea pigs immunized with various potential inactivated RS virus vaccines grown in different tissue cultures systems developed delayed dermal hypersensitivity when skin tested with vaccine materials. Animals immunized with alum containing vaccines developed more severe reactions than did animals immunized with aqueous vaccines. The addition of DPT vaccine to RS virus preparations also appeared to intensify the observed reactions. In addition, animals immunized with bovine kidney parainfluenza vaccine developed delayed dermal hypersen-sitivity when skin tested with bovine kidney RS vaccine. It appeared that both viral and host cell components of these vaccines were responsible for the observed reactions. Partially purified RS antigen A and B did not elicit delayed dermal hypersensitivity in animals immunized with these vaccines.
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