Abstract
Summary
Adult mouse peritoneal macrophages were infected with the Smith strain of mouse cytomegalovirus. Sequential observations were made on the development of cytopathic changes and the release of virus from cells. Virus production by macrophages and the appearance of typical intranuclear inclusions was slower than in mouse fibroblast cultures although the total amount of virus produced by the two types of cells was roughly equivalent. Macrophages in culture retained their phagocytic properties and were susceptible to the virus after uptake of carbon black. On the other hand, infected cells failed to phagocytize foreign carbon particles.
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