Abstract
Summary
Eighteen inbred mouse strains were exposed to 100% oxygen at 3 ATA to determine whether significant differences in oxygen tolerance exist among highly inbred strains. Significantly different survival times (mean survival time range = 9.8-21.7 hr) were demonstrated for certain strains. The form of toxic response to oxygen (pulmonary or central nervous system toxicity) varied between strains. At higher oxygen pressure (4 ATA) the proportional differences in mean survival times and variation in the types of toxic response to oxygen were maintained. Oxygen resistant mouse strains useful in evaluating HBO as a therapeutic agent for certain disease states have been delineated. Comparative studies of the inherent biochemical and physiological characteristics of these susceptible and resistant inbred strains could be useful in efforts to elucidate mechanisms of oxygen toxicity.
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