Abstract
Summary
The first disease symptom of influenza A2-infected mice was a reduction in water consumption. The degree of reduction with influenza A2/Bethesda/10/63 was virus-dose related whereas the time of appearance of this symptom was not. Amantadine HCl treatment of mice infected with influenza A2/Bethesda/10/63 and with influenza A2/AA/2/60 beginning 12 hr after the appearance of this disease symptom resulted in an increase in the percentage of survivors, an increase in survival time, an increase in the number of healthy animals, and an increase in the proportion of healthy to diseased animals of those which survived.
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