Abstract
Summary
The serum neutralization test utilizing the continuous line of rabbit kidney-cell strain LLC-RK1 has been found to be quite sensitive and reproducible. Some differences in results were found when neutralization tests were compared to HI tests. Performance of the HI test at an initial 1:4 dilution of serum appeared to be an important step in decreasing the possibility of false negative results. Even with this change, of 37 sera with no detectable HI antibody, 9 had antibody in the neutralization test. Clearly, there is a need to not only document serological results but to determine the true significance of these conflicting findings. These differences are important for the interpretation of serological tests for all clinical and vaccine studies.
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