Abstract
Summary
Subcutaneous nodules were induced at sensitization sites in guinea pigs injected subcutaneously with BCG organisms. When the organisms were suspended in water-in-oil emulsions, the size of the nodule was inversely related to the dose: 1.0 mg induced a larger lesion than 10 mg or 100 mg. Lesions induced by 1.0 mg of BCG were due primarily to delayed hypersensitivity, while lesions induced by 10 or more mg were due initially to toxicity and later to delayed sensitivity.
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