Abstract
Summary
Bilirubin production was found to increase twofold during the first 24 hr after administering 100 μg endotoxin (intraperitoneally) to rats. A 50% increase in bilirubin production was observed in host rats 7 days after transplant of the Walker carcinoma 256 (intramuscularly). Ability of the liver to conjugate bilirubin was normal in both types of animals. The results obtained are consistent with the view that the concomitant block in re-utilization of iron occurs at some point after its release from heme.
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