Abstract
Summary
Repeated injections of gold sodium thiomalate in guinea pigs resulted in significant weight gain. Retroperitoneal fat deposits and extractable omental fat were increased in treated animals. Neutron activation analysis and autoradiography localized gold within brain macrophages of treated animals. However, specific concentration of gold in hypothalamic nuclei and tissue destruction were not observed. The absence of lesions and the failure to demonstrate hyper-phagia suggest that gold thiomalate induces a metabolic obesity rather than a regulatory obesity in guinea pigs.
Get full access to this article
View all access options for this article.