Abstract
Summary
Administration of d-Penicillamine to weanling rats as 1% of the diet was found to produce marked osteolathyrism, with concomitant increases in urinary hydroxyproline and salt-soluble dermal collagen and decreases in dermal monoamine oxidase and proline hydroxylase activities. Supplementation of the diet with copper either partially or completely reversed the osteolathyritic and biochemical changes. Thus, an important role for copper in collagen synthesis is suggested.
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