Abstract
Summary
Experiments were undertaken in marmosets (Callithrix jacchus) to determine the tissue distribution of E. coli after intravenous inoculation and to investigate the susceptibility of the urinary tract of these animals to hematogenous or ascending infection. After intravenous inoculation of 107 E. coli, bacteria were rapidly cleared from the blood. High titers of bacteria were observed initially in liver and spleen but there was a rapid and progressive decline in number of organisms to complete sterility after 4 days. Pyelonephritis or bacteriuria did not result from hematogenous challenge. However, after inoculation of similar numbers of either E. coli or P. mirabilis into the lumen of the bladder, the majority of animals developed bacteriuria and 6 of 20 animals acquired pyelonephritis.
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