Abstract
Summary
3, 4-Dihydro-1-isoquinolineacetamide hydrochloride (DIQA) is a novel antiviral agent active in vivo against Columbia SK virus, herpesvirus, ECHO 9 virus (Coxsackie virus A23) and the PR8 and Japan 305/57 strains of influenza A virus. The substance was without effect in vivo against Coxsackie virus B1, Newcastle disease virus and influenza B virus. The compound was inactive when tested in tissue cultures against the viruses for which it had an antiviral effect in vivo. It was also inactive in tissue cultures against poliovirus type I and measles virus. Activity in vitro could be detected against Coxsackie virus B1 and vaccinia virus but, in the latter case, only if a plaque-reduction method was employed. The antiviral agent did not display anti-influenza activity in ovo.
Get full access to this article
View all access options for this article.