Abstract
Summary
Experimental thyroiditis and thyroglobulin autoantibodies have been produced in both complement intact and deficient mice by injections of a mixture of heterologous (cross-reacting) thyroglobulins without adjuvant. The severity of the immune response and incidence of thyroid lesions in mice varied from strain to strain. The Swiss Webster and A/JAX strains had the highest mean hemagglutinating antibody titer to homologous thyroglobulin in addition to being susceptible to thyroid lesions, whereas the complement intact and deficient strains of B10-D2/SN new line, DBA/1J, B10-D2/SN old line and DBA/2J showed autoantibody production without any definite thyroid lesions. Present data do not substantiate a necessary role for components of complement which are activated after the third component of complement in the production of either thyroiditis or autoantibodies in mice.
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