Abstract
Summary
Antithymocyte globulin was administered to 33 NZB-NZW F1 hybrid mice ranging from 36 to 47 weeks of age at the start of treatment. Thirty-one age matched female controls were studied. The ATG had a deleterious effect on survival, but no marked effect on renal histopathologic changes. The ATG did appear to prevent the development of fibrinoid arteritis. We speculate that the decrease in survival rate in the treated animals was related to an exacerbation of an underlying viral disorder.
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