Abstract
Summary
Cutaneous herpes simplex infection was produced experimentally in baby rabbits and hairless mice. Infection in rabbits progressed to give a flaccid hind limb paralysis, whereas massive skin lesions without the flaccid paralysis occurred in hairless mice. Progression of infection was readily scored in both baby rabbits and hairless mice so that these provided good systems for evaluation of antiviral agents. Kethoxal (α-keto-β-ethoxybutyraldehyde hydrate), a potent virucidal compound, showed marked antiherpes activity in both baby rabbits and hairless mice when applied topically. It is suggested that kethoxal may have potential utility in treatment of cutaneous herpes in man.
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