Abstract
Summary
Transplantation techniques in irradiated mice were used to demonstrate that the size of the population of colony-forming cells increases during the first 96 hr after injection of bone marrow cells into lethally irradiated animals. The doubling time in the population in the spleen was not constant, but was about 48 hr between 1 and 3 days decreasing to 24 hr between 3 and 4 days. Transplantation techniques probably grossly underestimate the size and growth-rate of the population of colony-forming cells in lethally irradiated mice injected with isogeneic bone marrow cells.
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