Abstract
Summary
Acid phosphatase activity in the peripheral blood cells of BALB/c/jax mice infected with Rauscher leukemogenic virus was demonstrated, using unfixed smears and azo dye coupling techniques. Enhanced enzyme activity was noted in neutrophils and lymphocytes with an increased percentage of cells staining and augmented numbers of granules per cell. A number of factors which could account for the rise in acid phosphatase are discussed. This activation of lysosomal enzymes may play a significant role in malignant cell transformation to the leukemic state.
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