Accumulation of Inorganic Sulfate by Choroid Plexus in Vitro ∗

Abstract

Summary

The incubation of choroid plexus tissue with ³⁵SO₄ ^2- reveals that sulfate is accumulated in the tissue against a concentration gradient. The magnitude of tissue accumulation appears to depend on cellular metabolism as evidenced by the adverse effect of metabolic inhibitors. The inhibition of sulfate accumulation by thiosulfate and thiocyanate implies that these anions share a common carrier. These findings support the contention that the low concentration of sulfate in CSF is due to the active transport of this ion out of the CSF across the choroid plexus.