Abstract
Summary
A method is described for detecting an aldosterone antagonist in unanesthetized adrenalectomized dogs maintained on long-acting replacement therapy. Using this method, spironolactone blocked mineralocorticoid effects on both Na and K excretion. The characteristics of the aldosterone antagonist were readily differentiated from those of a diuretic, chlorothiazide, by demonstration of qualitatively different effects on K excretion.
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