Abstract
Summary
Female RFM/Un mice exposed at various ages to whole-body X-radiation of 750 R followed by injection of syngeneic bone marrow cells showed a marked increase in megakaryocyte colonies in the spleen as the age of the mice at irradiation was increased from 30 to 72 weeks. A postirradiation splenic megakaryocytosis was also noted in a minority of similarly irradiated old mice which received no exogenous marrow cells. Hence, the megakaryocytes in the marrow-injected animals may be presumed to have been partially of host, as well as donor, origin. Variation in the age of the bone marrow donor over the same age range was without effect. The mechanism of the age-dependent megakaryocytosis in recipients remains to be determined.
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