Abstract
Summary
Dog aortas have been found to contain a Mg2+-stimulated inorganic pyrophosphate phosphohydrolase activity. The enzyme is maximally active at pH 7.5 and has a Km for PP i of 3 μM at this pH. This activity is extremely sensitive to inhibition by Ca2+. A role for this latter phenomenon in a postulated mechanism for the inhibition of calcification of the aorta is suggested.
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