Abstract
Summary
The development of a thymic lymphoma 4261/T in a mouse suffering from the chronic reovirus type 3 disease is reported. Transplantation of the tumor resulted in macroscopic lymphoma masses in the kidneys and/or jaw area. Low levels of reovirus antigen were found in the early transplantation passages. Antibody to reovirus was not detected in tumor-bearing mice from these passages. Mice from transplantation passages 12 and 13 showed evidence of reovirus type 3 infection with concomitant production of complement-fixing antibody to reovirus. Tests for reovirus in subsequent transplantation passages have proved negative. There has been no evidence to date for association of murine leukemia virus with lymphoma 4261/T.
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