Abstract
Summary
Reserpine-induced hypothermia occurs in the presence of shivering, piloerection, and hunched posture in contrast to the absence of these defenses following CPZ. Serum FFA and glucose levels remain normal in the reserpinized animal down to a body temperature of about 25°C below which they fall markedly. The CPZ induced hypothermia is associated with increases in serum FFA and glucose concentration proportional to the degree of hypothermia. Corticosterone levels are elevated with CPZ-induced hypothermia, but this increase is blocked by reserpine pretreatment. Serum insulin is unaffected by CPZ hypothermia, but the reserpinized animals have insulin levels elevated at 22°C and depressed at 3°C ambient temperature. In essence CPZ-induced hypothermia is associated with effective mobilization, but decreased utilization, of chlorigenic substrates. On the other hand, reserpine-induced hypothermia is associated with decreased mobilization of these substrates and their eventual depletion resulting from effective utilization.
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