Abstract
Summary
Sodium octyl, decyl, and dodecyl sulfate, in the concentrations used enhance the hypoglycemic effect of insulin in fasted and glucose-loaded rats. The molar relationships among these surface active agents indicate that higher concentrations of the shorter alkyl chain substances are required to produce the hypoglycemic effect. The adherence or penetration of insulin into rat liver cells has been measured by the hypoglycemic response of rats to injections of insulin-treated cells or the wash fluids of these cells. Detergents do not alter the adherence of the insulin to cells, but do decrease the amount of insulin present in the supernatant. This decrease is attributed to the penetration of insulin into the cells in the presence of detergent.
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