Abstract
Summary
The level of plasma erythropoietin (ESF) from untreated baboon renal allotransplants, compatibly or incompatibly matched in terms of their major human ABO blood groups, was assayed in polycythemic mice. Postoperative rises in ESF occur within 7 days if graft thrombosis ensues. Other grafts exhibit progressive elevations in ESF activity, which correlate directly with the reduction in measured renal blood flow due to renal rejection. Azotemia does not evidently influence this response in this species. Compatibly matched animals demonstrate continued ESF responses despite restoration of peripheral hematocrit values to preoperative ranges.
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