Abstract
Summary
Interferon production and antiviral activity by L cells treated with double-stranded synthetic polynucleotide complex I:C is increased up to one hundred times by addition of DEAE-dextran. Highest interferon production (300 units) was observed when I:C (10 μg/ml) and DEAE-dx (200-400 μg/ml) were held in contact with the cells for a 12-hour period. However increased amounts of interferon were also produced when the inducer and DEAE-dx were removed 2 hours after their addition and the cultures were reincubated for 10 additional hours. The inhibitor produced was shown to have properties consistent with those of interferon.
Get full access to this article
View all access options for this article.