Abstract
Summary
Two human subjects with total pancreatectomy showed very little absorption of orally administered cholesterol-4-14C following discontinuance of oral pancreatin. During this period their serum cholesterol dropped to under 100 mg/100 ml. When oral pancreatin was restored to one of the subjects, cholesterol was absorbed and the serum cholesterol level returned to 200 mg/100 ml. The results of the present study indicate that pancreatic secretions are necessary for the proper absorption of cholesterol and the maintenance of the blood cholesterol level in man.
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