Abstract
Summary
The 5-HTP (600 mg/kg, i.p.) reduced rat brain NE to 70% of control levels after 2 hours. The decrease in brain NE after large doses of 5-HTP may be due to inhibition of the biosynthesis of this biogenic amine. In support of this suggestion 5-HTP reduced both incorporation of tyrosine-14C into rat brain NE, and specific activity of the isolated NE. Data are also presented to show that the decrease in brain NE is not due to release such as that produced by reserpine or d-amphetamine.
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