Relative Insulinase Activity in the Liver and Kidney of the Rat ∗

Abstract

Summary

The insulinase activities of rat liver and kidney were compared by determining the amounts of insulin-¹³¹I degraded by homogenates and subcellular fractions of these organs. The insulinase activity of rat kidney was greater than that of rat liver when compared on the basis of gram wet tissue, “Mitochondria-free” fractions of rat liver had 67% of the insulinase activity of the “nucleus + debris-free” fractions; whereas, “mitochondria-free” fractions of rat kidney had 28%.