Abstract
Summary
Adenoviral serotypes 1, 7, 8, 14, 21, and 24 were inoculated into thymectomized and nonthymectomized newborn Syrian hamsters because of their suspect oncogenicity in an initial screening program. Enhanced oncogenicity attributable to thymectomy at 1 week of age was observed when type 7 was inoculated subcutaneously. Tumor incidence increased from 4 to 17%. About 14% of the thymectomized hamsters inoculated with adenovirus 21 had tumors although this virus produced no tumors in intact animals of this series. All surviving animals remain under observation.
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